Relevant to many preclinical studies are the extensive investigations in male C57BL/6 mice that are summarized in Table 1 and compared with the data from insulin-resistant humans, because many cancer patients are also insulin resistant
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They enhance barrier function stabilizing claudins 2 and 4 and occludin at tight junctions in mice models of necrotizing enterocolitis
The studies that were used to gain FDA approval for these drugs included few adults over 64 years of age
Similarly, although patients treated with exenatide or liraglutide may experience injection-site reactions and, rarely, localised transient urticaria, the skin has not traditionally been viewed as a site of incretin action