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Patients are commonly required to increase dosage amounts as well as the frequency of doses, requiring a dose every 2-3 h, for example [44]

121 Mutations in the progranulin gene, GRN , which cause a genetic familial FTD, downregulate expression of EAAT2 astrocyte glutamate transporter, which mediates synaptic degeneration

This is significant since the visualization of a spindle is predictive of embryonic developmental competence (146)

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In summary, while dietary supplements offer significant potential to improve oocyte quality, a more systematic and standardized approach is urgently needed to bridge the gap between preclinical discoveries and clinical applications