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This may be due to the limited temporal window of our MRS measurements or could indicate that downstream mechanisms, such as AMPA receptor activation, neuroplastic signaling pathways (for example, BDNF or TrkB and ERK or mTOR) or effects in regions beyond the ACC, are more critical targets for mediating antidepressant response

Comparison of conformers 1 and 2 revealed that the orthosteric pocket of conformer 2 is more open than that of conformer 1 (Fig