The study utilized a single-blind, randomized, placebo-controlled, crossover design, combined with functional magnetic resonance imaging (fMRI), to analyze the performance of 54 participants (30 with normal insulin sensitivity and 24 with impaired insulin sensitivity) on sensory associative learning tasks while receiving liraglutide and placebo treatments.435 Liraglutide significantly enhanced associative learning abilities in obese individuals with impaired insulin sensitivity
The New England journal of medicine, 387(3), 205216
If youre in one of these groups, ask your doctor whether you could benefit from taking a combined B1, B6 and B12 vitamin complex like Vitamins B1+B6+B12 (NEUROBION) or Vitamins B1+B6+B12 (NEUROBION Forte)
The way it works makes sense: GLP-1 mostly changes the brainstem circuits that control feeling full, while amylin changes the area postrema and the nucleus tractus solitarius, which affects different neural paths
These effects might be facilitated via AMPK/Sirtuin 1 (SIRT1), autophagy, and the Toll-like receptor-4 (TLR-4)/NF-B/NLRP3 signal transduction cascade [264]