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The computational experiments presented in this paper were carried out using the HPC facilities of the University of Luxembourg [75], Ethics declarations Competing interests The authors declare no competing interests

CLEM, 3D ET analyses, and immuno-EM reveal a plant-unique population of spherical vesicles (~3050 nm in diameter), with nascent vesicles budding from MVBs Given that plant retrograde transport likely to mediate the retrieval of VSRs from MVBs, we utilized CLEM and 3D ET to systematically identify and analyze potential structures around MVBs

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From a systems-biology perspective, combined evaluation of BPC-157 and TB-500 is based on the hypothesis that each peptide may support distinct rate-limiting steps, such as cellular recruitment, cytoskeletal adaptation, vascular organization, and remodeling-stage signaling rather than duplicating identical biological effects (1,3,12)