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Mechanical stress and mitochondrial dysfunction also contribute significantly to the induction of senescence in chondrocytes, disrupting their homeostasis and regeneration potential (Sophia Fox et al., 2009

In the SUSTAIN clinical trial program, cases of pancreatitis were reported, but at rates that did not reach statistical significance in most individual studies when compared to control groups

However, the directionality and causality of this relationship remain unclear

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