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Histologic examination showed a decrease in testicular epithelium thickness and atrophy of the seminiferous tubules in irradiated controls [45]

Histopathologic analysis of the colonic biopsies confirmed the presence of severe melanosis

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Second, the patient should meet established criteria for pharmacologic weight management intervention, such as BMI 30 kg/m or BMI 27 kg/m with weight-related comorbidities, consistent with FDA indications

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