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Beyond the two primary proteins of focus in ADRD progression, glymphatic clearance also helps support removal of inflammatory markers to maintain the parenchymal environment and reduce neurotoxic load on neurons (Mogensen et al., 2021)

Some components are considered protective and are beneficial for gut health

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The STEP 1 trial demonstrated a mean body weight reduction of 14.9% at this dose after 68 weeks, with 86.4% of participants achieving at least 5% weight loss and 69 to 79% achieving 10% or more