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MHRA/EMC SmPCs for liraglutide and semaglutide) Common Incretin Drugs Used in the UK Several incretin-based medications are currently licensed and available through the NHS in the UK, falling into two main categories: GLP-1 receptor agonists (including dual GIP/GLP-1 receptor agonists) and DPP-4 inhibitors

The TRIUMPH 4 trial specifically enrolled adults with obesity or overweight who also had knee osteoarthritis

Serious Side Effects and Risks Even the safest treatments carry some risk, but adopting simple habits can help mitigate side effects

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The 23andMe data suggest that a definable genetic subgroup exists with higher GLP-1R expression