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The GSH level is increased and hippocampal neuron loss is decreased when NAC and sulforaphane combination treatment is applied to epileptic rats
When ligands (such as IS, IAA, and kynurenine) bind to AhR, AhR is released from the chaperone protein complex and translocates to the nucleus, where it heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), then binds to xenobiotic response elements (XRE) or dioxin response elements (DRE) to induce downstream target gene transcription (120)
Animal Studies: Demonstrated 4x higher bioavailability in plasma and sustained organ deposition 4
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