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Journal of Aesthetic Nursing , 4(5), 220227

The risk of renal adverse reactions was increased in patients with a history of renal impairment (the weight management trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration

In-vitro (made in the lab) studies also show that Asiaticoside stimulates GAGs (glycosaminoglycans - polysaccharides that are part of the liquidy stuff between our skin cells) production as well as collagen I synthesis

& Yuste, R

Inoue, Masaki, Haruhiko Kamada, Yasuhiro Abe, Kazuma Higashisaka, Kazuya Nagano, Yohei Mukai, Yasuo Yoshioka, Yasuo Tsutsumi, and Shin-ichi Tsunoda