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Max-Planck-Institut fr Biochemie, Abt

105 Hyperglycemia initiates a positive feedback loop involving the tyrosine kinase ErbB4 and the mammalian target of rapamycin (mTOR), contributing to tau hyperphosphorylation under hyperglycemic conditions

Dutasteride (brand name Avodart) is a 5-alpha reductase inhibitor originally approved by the FDA for benign prostatic hyperplasia, an enlarged prostate condition

Advances in high-resolution technologies such as single-cell omics, spatial metabolomics, and imaging mass spectrometry have progressively unveiled the metabolic heterogeneity landscape within CRC [130, 131]