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Complete loss of GPX4 is incompatible with viability, and pharmacological or genetic GPX4 inhibition is widely exploited to induce ferroptosis in cells and tissues

It has further surprisingly and unexpectedly been found that multiple agent therapy, such as wherein each agent is independently a sub-therapeutic dose, with either sequential or concurrent administration of the agents, will produce the desired pharmacological response, such as an erection sufficient for sexual intercourse, with higher reliability than does a higher dose of either agent administered as monotherapy that in some instances produces the desired pharmacological response

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