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Acknowledgements We thank all the laboratory members for helping with reading and commenting on the manuscript

The selectivity is documented in the foundational paper: a peer-reviewed European Journal of Endocrinology study demonstrating that Ipamorelin stimulates growth hormone selectively without elevating ACTH, cortisol, or prolactin, which is exactly why it has become the default selective secretagogue in modern peptide medicine

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Wang L, He W-B, Yu X-M, Hu D-L, Jiang H

It binds MC1R (melanogenesis), MC3R (inflammatory modulation and energy homeostasis), MC4R (appetite suppression, erectile function, cardiovascular tone), and MC5R (exocrine gland function) with roughly similar affinity