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In Ldlr / Leiden mice, only the combined intervention with nicotinamide riboside, rather than either monotherapy, significantly attenuated obesity and hepatic steatosis, accompanied by coordinated upregulation of genes involved in fatty acid oxidation and insulin signaling (61)

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Retatrutide's longevity significance extends beyond weight loss: its effects on liver fat, glycemic control, and potentially cardiovascular and neurological outcomes position it as a multi-pathway intervention on metabolic aging