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Tirzepatide (Mounjaro, Zepbound, compounded) Tirzepatide dual GIP/GLP-1 mechanism produces robust weight loss and glycemic control, but the shorter half-life means slightly less flexibility in timing

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Rather than scavenging radicals on contact, it upregulates endogenous antioxidant enzyme systems at the gene expression level, including SOD, catalase, and glutathione peroxidase

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We also explore the use of sodium-glucose co-transporter-2 (SGLT-2) inhibitors, amylin mimetics, leptin analogues, ghrelin antagonists and centrally acting agents to suppress appetite [neuropeptide Y (NPY) antagonists, melanocortin-4 receptor (MC4R) agonists and cannabinoid-1 receptor antagonists]