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To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen

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In addition, the expression of DMT1 was upregulated, while the expression of FTH1, SLC7A11, and GPX4 was downregulated

Distler JHW, Gyorfi AH, Ramanujam M, Whitfield ML, Konigshoff M, Lafyatis R

GHK-Cu promotes skin healing, collagen production, and anti-inflammatory effects that may benefit lupus-related skin involvement