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Viral Immunol 18:457465 Fine SM, Angel RA, Perry SW, Epstein LG, Rothstein JD, Dewhurst S, Gelbard HA (1996) Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes

There is also a specific biological reason the systemic route attracted attention

GoesslerWKuehneltDSchlagenhaufenCKalcherKAbegazMIrgolicKJ.Retention behavior of inorganic and organic selenium compounds on a silica-based strong-cation-exchange column with an inductively coupled plasma mass spectrometer as selenium-specific detector

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