DMF, via the covalent modification of KEAP1 cysteine residues, leads to reliable NRF2 stabilization, with dose-dependent effects that are cytoprotective at low doses
Distinct BOLD activation profiles following central and peripheral oxytocin Administration in Awake Rats
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However, the efficacy of this passive targeted delivery is low, and sufficiently high levels of drug concentrations at the tumor sites are not generally seen in practice
Other studies yielded contradictory results, though, with outcomes unsupportive of a beneficial effect on maximal aerobic capacity, blood lactate response, or changes in respiratory exchange ratio during exercise [39,40,41,42,43]