Naltrexone/bupropion, semaglutide, tirzepatide, and liraglutide compared Naltrexone/bupropion is not the only medication-based approach that may play a role in medical weight loss
Semaglutide Dose Ranges and Weight Loss Outcomes Research from the STEP clinical trials demonstrated that weekly semaglutide doses of 0.5 mg, 1.0 mg, and 2.4 mg produced dose-dependent weight loss, with average reductions ranging from 5% to 18% of baseline body weight over 68 weeks
Standard protocols using 1 to 2 mg daily are operating at a tiny fraction of these thresholds
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For Wegovy and Mounjaro, the person must be obese and have at least one obesity-related health problem such as sleep apnoea or high blood pressure
