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It is important to note that Semaglutide should be used as part of a comprehensive weight management plan, which includes a healthy diet, increased physical activity, and behavior modifications

For additional guidance, refer to the FY2026 ICD-10-CM Official Guidelines, the AHA Coding Clinic, and the Amputee Coalition Healthcare Professional Resources for clinical background on amputation rehabilitation

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Stool softeners such as docusate sodium (Colace) have minimal evidence supporting their efficacy as monotherapy and are generally not recommended alone for semaglutide-induced constipation

In our clinical experience, tirzepatide seems to cause less side effects than semaglutide