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Based on the derived sensitivity and specificity, performance metrics including positive predictive value, negative predictive value, number needed to screen, and number proceeding to PET scan were calculated based on a prevalence of amyloid PET positivity of 25% 31

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This translocation activates toll-like receptors (TLRs), including TLR4, in microglial cells within the brain, triggering neuroinflammatory responses

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