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Emerging DDSs for gout and hyperuricemia, including zinc ferrite nanoparticles and synthetic gene networks, demonstrate innovative mechanisms such as self-regulated enzyme activity and biomimetic catalysis

Mechanistic plausibility exists for tissueprotective and reparative effects through modulation of angiogenesis, NO signaling, and inflammatory pathways, but translation into standardized therapeutic regimens for humans remains to be established by rigorous clinical research

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