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The primary mode of NRF2 regulation is at the protein level, with three primary E3 ubiquitin ligase complexes mediating the ubiquitylation and subsequent degradation of NRF2 by the 26S proteasome: 1 ) KEAP1-CUL3-RBX1, 2 ) HRD1 (also known as synoviolin), and 3 ) SCF/-TRCP

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