Effects were comparable to prednisolone, without the weight gain, metabolic disruption, or bone density loss associated with corticosteroids (PMC2095288)
C., Wagner, T
Long-term PPI use (beyond 1 year) has its own set of considerations, including potential effects on calcium absorption, magnesium levels, and vitamin B12 status
Recent studies have revealed that dysregulation of mitochondrial dynamicsincluding impaired mitophagy, imbalances in mitochondrial fusion and fission, and defects in mitochondrial biogenesisis closely associated with CRC initiation, progression, and resistance to therapy [46]
In the last 6-8 years, groundbreaking studies have shown the huge benefits of these medications, including reducing dementia, heart disease, and 23 obesity-related cancers, and the list continues to grow