Glutathione (GSH) is a tripeptide with a gamma peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain
For approved peptide drugs, half-lives are well established from human pharmacology
[Google Scholar] 5.The beneficial effects of N-acetyl cysteine (NAC) against obesity associated complications: a systematic review of pre-clinical studies

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3a), whereas its upregulation made cells more resistant (Fig