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Intracerebroventricular KYNA infusions similarly impair conditioned orienting to visual cues, highlighting its role in disrupting attentional processing and implicating glia-derived KYNA in cognitive deficits relevant to neuropsychiatric and neurodegenerative disorders [76]

Changes that naturally affect the spine with age, such as thickened spinal ligaments, can also contribute to degenerative spinal stenosis