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This decoupling suggests that neuroinflammation may become an autonomous process or that symptoms are maintained by lasting neuroplastic changes (e.g., primed microglia)

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Retinol is an over-the-counter form of Retinoic Acid that requires the activation of enzymes before it can be used, which reduces its efficacy

Concurrently, genetic and epigenetic profiling is being incorporated into large-scale prospective studies to further clarify gene-environment interactions, identify biologically vulnerable subgroups, and build individualized risk models 29