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In addition, associations between GLP-1R activation and coronary artery disease and parental mortality, a proxy for all-cause mortality, were investigated, as GLP-1RAs have been reported to reduce cardiovascular events and deaths

Semaglutide is a glucagon-like peptide (GLP)-1 receptor agonist primarily used in type 2 diabetes treatment and has also increased in use as a weight loss drug

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This doesn't indicate failureappetite normalization is expected biology