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Taken together, the varying sensitivity of the five cell lines and the difference in toxicity between the three metals suggested that (i) there may be cell typespecific differences contributing to metal toxicity, and/or (ii) toxicity may be mediated by metal-intrinsic features, including differences in the mechanisms of toxicity and the respective cellular responses

A major enzyme of steroid hormone metabolism that utilizes NADPH is the ER-localized 11-hydroxysteroid dehydrogenase 1 (11-HSD1) which is encoded by the HSD11B1 gene

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