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GLP-1 agonists directly bind these receptors, triggering insulin secretion, slowing gastric emptying, and increasing satiety

Altogether, this dataset suggests that prolonged, but not acute, activation of GLP-1R induces metabolic reprogramming leading to increased glycolysis and cellular hypertrophy in BRIN-BD11 cells

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The full titration to an effective dose takes 12 to 16 weeks for most patients