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An experiment also revealed that UA enhances autophagy flux during bacterial infection, thus reducing the release of IL-1 and inflammasome activation in macrophages [52]

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Maintaining normal carnitine homeostasis is vital for mounting an immune response, especially in the case of severe infection such as sepsis [70]

On the contrary, BDH2 overexpression has been associated with poor overall survival in cytogenetically normal AML (70) and with elevated ferritin levels as well as an increased risk for progression to leukemia in MDS (71)