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If much of the Glutathione within a cell has been oxidized, it seriously compromises the cells entire antioxidant system and ability to protect itself

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conversely, Mucispirillum and Clostridium were markedly depleted, while Lachnospiraceae_UCG_004 showed moderate but significant upregulation

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A monothiol mechanism was also reported for the in vitro reduction of mammalian RNR 46 and can be also employed, although with a decreased activity, by a Grx-RNR fusion protein from Facklamia ignava 47