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GSH depletion triggered by the Nrf2/ATF3/4/ChaC1 pathway appears to be the primary factor inducing death in drug-resistant tumor cells (138), positioning ChaC1 as a key target for certain potential anti-tumor drugs such as busatol (139) and glaucocalyxin A (140)

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Tribedoce Compound is contraindicated in patients with a history of hypersensitivity to Diclofenac, other non-steroidal anti-inflammatory drugs (NSAIDs), or any of the formula's components