According to FDA prescribing information, abdominal distension (the medical term often used to describe bloating) is listed among the reported adverse reactions for semaglutide products
The evidence for these is less robust than for simethicone, but many users report subjective improvement
Training type considerations: High-impact activities (running, jumping) tend to be more uncomfortable during bloating than low-impact options (cycling, swimming, weight training)
For a semaglutide user, weight-management endpoints (body fat, waist circumference, energy intake) are the most directly relevant available evidence, given that the broader bloating-specific evidence is weak across the category
However, some compounded formulations include additional ingredients like glycine or methylcobalamin that may modestly improve GI tolerance