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International Journal of Molecular Sciences, 21 (22), 8637

Specifically, attenuation of MAPK pathway activation may contribute to the reduction of inflammatory and stress responses following irradiation, whereas regulation of Rap1-associated signaling may be involved in the maintenance of adherens junction-related proteins, including -catenin and E-cadherin, thereby supporting intestinal barrier integrity

Far from being a static microenvironment, pericardial fluid not only provides homeostatic support to the heart, but also dynamically reflects cardiac injury and regulates its function by stocking bioactive molecules, some of which have been identified including cytokines, chemokines, growth factors, matrix metalloproteases (MMPs), or lipid mediators 38,39,40,46