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The pharmacokinetic considerations and adverse effects of DPP-4 inhibitors

Nearly half of the participants (48%) experienced at least a 50% reduction in headache frequency, and 23% achieved a 75% or greater reduction

In our hands, however, the GLP1R antagonist exendin-9 had negligible effects on either basal I sc or I sc responses to AngII (Supplementary Figure 3), indicating that GLP1R was not required for the observed responses to AngII