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This decrease can be accelerated by poor lifestyle choices like an unhealthy diet, inactivity, or toxin exposure contributing to increased oxidative stress linked with age-related conditions

One study called the prevalence of optimal metabolic health alarmingly low, with only one in eight adults meeting the criteria

Zhu H, Zhou L, Wang Q, Cai Q, Yang F, Jin H et al (2023) Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort

Retrieved November 30, 2025 American Academy of Sleep Medicine

[22,23,26] In addition, it is interesting to note that the action of NAC goes beyond mere structural neuroprotection to include benefits extending to behavioural and psychiatric outcomes [Figure 7]