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PD98059, an inhibitor used to reduce MEKERK signaling, lowered several of the measured responses

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The resulting downregulation of JMJD3 leads to suppressed EDNRB expression and compensatory upregulation of EDNRA, promoting endothelin-mediated vasoconstriction, ERK pathway activation, and vascular remodelingall key features of hypertension [55,56,57]

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