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Instead of being injected weekly and providing better weight loss results like semaglutide in Ozempic and Wegovy, or tirzepatide in Mounjaro, this is actually associated with smaller weight loss than the other three.

Its value in a clinical setting comes from what it is not: it does not disrupt appetite, hormones, insulin, or IGF-1

The majority of the evidence in our manuscript included case reports, retrospective case-control, and cohort studies, which are inherently associated with a risk of bias, particularly when confounding factors are not adequately adjusted [40, 41]

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Moreover, the VEGF hypothesis does not fully account for the inflammatory component of DR pathogenesis