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Many are mild and manageable

doi: 10.1038/s41467-019-14132-y

Diabetes Obes Metab 27(2):806815 Simms-Williams N, Treves N, Yin H, Lu S, Yu O, Pradhan R et al (2024) Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population-based cohort study

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When these receptors activate in blood vessels and the autonomic nervous system, they can promote vasodilation (widening of blood vessels), which naturally lowers pressure