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This study can be a node for developing more mature and controlled studies to evaluate the effect of vitamin B12 as a safe and potentially important moderator of nociplastic pain and psychological illness in FM

5 Immunohistochemistry of tumor necrosis factor- (TNF-) in the dorsal root ganglion (DRG) and spinal cord (SC) at phases (A) 1 and (B) 2 1

Both studies observed the same biphasic dose-response

Although the data was collected for GHK without copper, we cannot exclude the possibility that the actual gene regulator was the GHK copper complex formed in the culture media, since, as it was mentioned above, GHK can easily obtain copper from other biological molecules such as albumin

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