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Cell extracts were centrifuged at 14,000 rpm for 15 min at 4C

This decreases the darker eumelanin and increases the lighter pheomelanin, leading to a lighter and fairer skin tone

It helps disintegrate the mucus accumulation in the respiratory pathways and reduce overall inflammation, causing the swelling

Similar to rapamycin 31 , these effects were achieved even though not initiated until later in life, which we reasoned to be a safer therapeutic window for IGF-1R modulation than younger ages 34