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In the DPP-4/Diprotin A co-crystal structure (PDB ID 1nu8), the peptide bond between the second and third residues is not cleaved after formation of the tetrahedral intermediate, wherein the sidechain of the catalytic serine (Ser630) is covalently linked to the carbonyl carbon atom Pro2

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The cells were incubated in this condition for another 12 h

However, GLP-1 drugs were associated with a slightly higher rate of uveitis when compared with SGLT2i agents, which also conferred a reduced uveitis risk when compared with controls