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However, maximal benefit often emerges after 3-6 months as cumulative weight loss and sustained GLP-1 receptor activation take full effect

Billy Tollett: What surprised me the most about my journey was probably how I bought into it like a religion almost

Incretins are gut-derived hormones that are secreted after eating and help stimulate insulin secretion in response to glucose

J Pharm Investig 54:145160

The most realistic approach for most people: use the keto plus GLP-1 combination during the active weight loss phase (typically 6 to 18 months), then transition to either maintained keto as a GLP-1 exit strategy, continued GLP-1 at a maintenance dose with a more moderate low-carb diet, or a gradual return to a protein-prioritized diet that may include more carbohydrates than strict keto while maintaining the metabolic awareness and habits built during the keto phase