Metabolism (2017) 68:13344.10.1016/j.metabol.2016.12.009 154 CaniPDAmarJIglesiasMAPoggiMKnaufCBastelicaDet alMetabolic endotoxemia initiates obesity and insulin resistance
Transfer of nanocarriers across the BBB and biological effects The main goals for BBB-targeted nanocarriers are at least three-fold, namely increase solubility, enhance brain penetration to reach better therapeutic efficiency, and minimize peripheral side-effects
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), which is particularly stable in plasma samples stored at 80C for up to 5 years, can be used to precisely analyze TMAO [5, 85, 86]
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Together, they create a strong defense against illness and improve overall well-being