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If heart failure develops, dosage reduction or discontinuation of the TZD must be considered

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Types of outcome measures Primary outcomes Primary outcomes included PD motor impairment as measured by the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) subscale Part III in the on-medication state in endpoints and midpoints of included studies and in the off-medication state in endpoints and midpoints of included studies [19]

(Kato et al., 2022) As the mucins are secreted and insufficiently hydrated, the viscosity and elasticity of the mucus increase and make mucociliary and cough clearance more difficult (Tambascio et al., 2013