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247 Mechanistically, it is unclear how GLP-1-based therapies exert beneficial effects on the cardiovascular system, but studies have suggested that this is achieved by direct (cardiovascular GLP-1R activation) and indirect (promotion of the incretin effect) mechanisms

Cell 172, 409e21

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Toxicol Pathol 37, 9971005

it is produced by traditional organic synthesis and supplied as a crystalline solid for laboratory reconstitution in a research-appropriate solvent