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Because these treatments actively slow down your entire GI system, using the wrong over-the-counter options can make your symptoms significantly worse

The low-specificity L-threonine aldolase LtaE, which cleaves several L-3-hydroxy--amino acids, like HTML, to glycine and a corresponding aldehyde and which may accommodate molecules larger than L-threonine in its large substrate binding pocket (di Salvo et al., 2014), may exhibit side activity as HTML aldolase

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Cancer Cell (2015) 27(1):4156