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Indeed, the establishment of analyte databases like ChemSpider (165) and the Human Metabolome DataBase (166), along with integration tools like the Kyoto Encyclopedia of Genes and Genomes (167) and MetaboAnalyst (168), has enabled easier feature annotation and allowed for an expansion of the number of analytes that can be definitively identified

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The metabolites and proteins that contribute to ROS production in the nucleus remain to be identified

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